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Alex Peniche

Position      Adjunct Instructor of Biology
Phone         409-944-1378
Office          M-314

Email           apeniche@gc.edu

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Academic qualifications

Universidad del Valle, Colombia
Doctorate - Biomedical Science
January 2014

Universidad del Valle, Colombia
Master - Basic Medical Sciences
January 2007

Universidad del Valle, Colombia
Bachelor – Biology
January 2001

OTHER QUALIFICATIONS

Post-Doctoral Certificates; University of Texas Medical Branch
- Effective Teaching and Mentoring
- Translational Research Team Management
- Advanced Biomedical Research Strategies

Diploma in Academic Management Skills
Fundación Universitaria del Area Andina. Bogotá, Colombia
2007 - 2008

POSITIONS HELD

Research Associate, Post-doctoral Fellow
University of Texas Medical Branch (UTMB), Galveston, TX
2010 - present

Research Scholar
University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX
2008 - 2010

Research Professor
Fundación Universitaria del Area Andina, Bogotá, Colombia
2006 - 2008

Research Assistant
CIDEIM, Cali, Colombia
1999 - 2006

Teaching Assistant
Universidad del Valle, Cali, Colombia
General biology, Evolution, Animal physiology, Plant Genetics
1994 - 1997

PUBLICATIONS

Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SM. Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity. Anaerobe 2018 Aug 9; 54:83-91

Reyes VE, Peniche AG. Helicobacter pylori deregulates T and B Cell Signaling to Trigger Immune Evasion. Submitted to Current Topics in Microbiology and Immunology (8/7/2018)

Peniche AG, Bonilla DL, Palma GI, Melby PC, Travi BL, Osorio EY. A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis. PLoS One. 2017 Jun 7;12(6):e0179084

Andersson JA, Fitts EC, Kirtley ML, Ponnusamy D, Peniche AG, Dann SM, Motin VL, Chauhan S, Rosenzweig JA, Sha J,Chopra AK. New role for FDA-approved drugs in combating antibiotic-resistant bacteria. Antimicrob Agents Chemother. 2016 May 23;60(6):3717-29.

Peniche AG, Renslo AR, Frantz DE, Melby PC, Travi BL. Antileishmanial activity of disulfiram in an ex vivo system is enhanced by the addition of divalent metal ions. Antimicrob Agents Chemother. 2015 Oct;59(10):6463-70. 

Snook JD, Chesson CB, Peniche AG, Dann SM, Paulucci A, Pinchuk IV, Rudra, JS. Peptide nanofiber-CaCO3 composite microparticles as self-adjuvanting oral vaccine delivery vehicles. J. Mater. Chem. B, 2016 (4):1640-9

Peniche AG, Osorio Y, Renslo AR, Frantz DE, Melby PC, Travi BL. Development of an ex vivo lymph node explant model for the identification of novel molecules active against Leishmania (L.) major. Antimicrob Agents Chemother.  2014 Jan;58(1):78-87.

Peniche AG, Savidge TC, Dann SM. Recent insights into Clostridium difficile pathogenesis. Curr Opin Infect Dis. 2013 Oct;26(5):447-53.

Ibrahim MK, Barnes JL, Anstead GM, Jimenez F, Travi BL, Peniche AG, Osorio Y, Ahuja SS, Melby PC. The malnutrition-related increase in early visceralization of Leishmania donovani is associated with reduced lymph node cellularity and phagocytic capacity, and altered conduit system flow. PLoS Negl Trop Dis. 2013 Aug;7(8):e2329.

Osorio Y, Rodriguez LD, Bonilla DL, Peniche AG, Henao H, Saldarriaga O, Travi BL. Congenital transmission of experimental leishmaniasis in a hamster model. Am J Trop Med Hyg. 2012 May;86(5):812-20. 

Osorio Y, Travi BL, Renslo AR, Peniche AG, Melby PC. Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system. PLoS Negl Trop Dis. 2011 Feb 15;5(2):e962.

Travi BL, Osorio EY, Saldarriaga OA, Cadena H, Tabares CJ, Peniche AG, Lee S, Melby PC. Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes. Am J Trop Med Hyg. 2009 Dec;81(6):994-1003.

Laza C, Peniche AG, Castillo LR, Silva PA, González LF. The pray: a cultural care practice for American cutaneous leishmaniasis in Florian, Santander (Colombia). Index Enferm 2009. 18(3): 151-155.

Osorio Y, Bonilla DL, Peniche AG, Melby PC, Travi BL. Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. J Leukoc Biol. 2008 Jun; 83(6):1413-22.

Abstracts in Scientific Meetings

Peniche AG, Dann SM. 2015. Effect of age on Clostridium difficile infection in a murine model of infection FASEB J April 2015 29:766.122.

Snook J, Rudra J, Dann S, Peniche AG. Peptide Nanofiber-Calcium Carbonate Composite Microparticles for Mucosal Vaccine Delivery. ID #1756. Biomedical Engineering Society. October 7-10, 2015 in Tampa, Florida (USA).

Spinler JK, Ross C, Auchtung JM, Navarro JB, Haag AM, Brown AK, Luna RA, Runge J, Versalovic J, Dann S, Peniche AG, Garey KW, Goodman SD, Britton RA, SavidgeT. Symbiotic targeting of Clostridium difficile. CLOSTPATH 2015 in September 7-11 in Freiburg, Germany.

Dann S, Kelly H, Suarez D, Hoppe D, Banks M, Peniche AG. 2015. Luminal-GABA promotes inflammation in mouse models of colitis. J Immunol 2015 194:66.7:138.14

Dann S, Eaves-Pyles T, Peniche AG, Choudhury B, Feng H, Savidge T. 2014. Microbiota-derived GABA exacerbates Clostridium difficile-associated intestinal inflammation and suppresses development of protective immunity. J Immunol 2014 192:66.7

Tessier ME, Andersson H, Ross C, Peniche AG, Dann S, Francis M, Sorg J, Thevananther S, Savidge T. Mo1850 Obeticholic Acid (INT-747) Confers Disease Protection Against Clostridium Difficile Infection. Gastroenterology, Vol. 148, Issue 4, S-726

Tessier ME, Urvil PT, Ross C, Mistretta T, Chacko SK, Francis M, Sorg J, Peniche AG, Dann SM, Garey KW, Savidge T. 2014. Enterohepatic biomarkers of microbial pathogenesis in Clostridium difficile infection (1171). Hepathology 60(4) supp: 767A.

Spinler JK, Boonma P, Hollister EB, Dann SM, Peniche AG, Sontakke A, Versalovic J, Savidge T, Tumwasorn S. 2013. Supplementation with lactobacillus is a viable option for preventative treatment of recurrent Clostridium difficile-associated diarrhea (5). Probiotics, Prebiotics, and the Host Microbiome: 34

Ibrahim MI, Peniche AG, Travi BL, Anstead G, Melby PC. Lymph node dysfunction in experimental model of malnutrition and visceral leishmaniasis. AmJTropMedHyg 85(6supp 1):101

Peniche AG, Osorio EY, Melby PC, Travi BL. 2010. Development of a medium throughput system that uses lymph node ex vivo explant cultures to identify compounds against cutaneous leishmaniasis. Am J Trop Med Hyg 83(5 supp 1):205

Peniche AG, Osorio EY, Travi BL, Renslo AR, Melby PC. 2009. Identification of new aminoquinoline compounds active against visceral leishmaniasis using an ex vivo model system. Am J Trop Med Hyg 81(5 supp 1):217

Peniche AG, Osorio EY, Melby PC, Travi BL. 2006. Neutrophil infiltration is associated with initial parasite control but subsequently contributes to tissue damage in hamsters infected with Leishmania (Viannia) panamensis. Am J Trop Med Hyg 75(5):148

Osorio EY., Bonilla DL., Peniche AG., Travi BL. 2005. Congenital transmission in experimental leishmaniasis. Am J Trop Med Hyg 73(6):311

Peniche AG., Travi BL, Osorio EY. Role of neutrophil in parasite control of American Cutaneous Leishmaniasis. Biomédica 25(S1):126

Osorio EY., Bonilla DL., Peniche AG., Rodriguez LD, Saldarriaga O, Melby PC, Travi BL. Experimental study of congenital transmitted cutaneous leishmaniasis. Biomédica 25(S1):126

Osorio EY., Bonilla DL., Rodriguez LD, Saldarriaga O, Peniche AG., Travi BL. Impact of visceral leishmaniasis in pregnancy and congenital transmission of L. donovani. Biomédica 25(S1):125

Peniche AG, Osorio Y & Travi B. 2003. Pathogenicity and metastatic ability in the hamster model of strains of Leishmania (Viannia) panamensis isolated from patients with cutaneous and mucocutaneous cases. Biomédica 23(S1):51

Peniche AG, Osorio Y & Travi B. 2003. Comparative study of the pathogenicity of Leishmania braziliensis and Leishmania panamensis in the hamster model. Biomédica 23(S1):59